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On top of the already discussed benefits for energy levels and combating stress, taking vitamin B12 on an empty stomach will aid absorption by creating an acidic environment the same goes for all nutrients that are not fat-soluble
Bioavailability refers to the proportion of a nutrient that enters the circulation when introduced into the body and is so able to have an active effect
Circulation 103(2):207212
Adequacy of vitamin supply under maximal sustained workloads: the Tour deFrance
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